Here you will find the keys to understanding the causes of this pathology, the mechanisms involved and how to treat them.

A condition once reserved for adolescence, acne is now a problem encountered by more and more adult women. Implementing these recommendations should allow you to both improve the quality of your skin and also a general well-being and avoid other pathologies because the causes of acne reveal some global imbalances that are important to treat. Acne is a common dermatological disease characterized by the presence of comedones, blackheads and microcysts that are often red (inflammatory), large and white (excess sebum). These lesions are mainly located on the face (cheeks, forehead, chin), neck and back. In the longer term, it can give rise to persistent scars, which is why it is important to treat them quickly. It is important to note that acne is a modern disease, due to our Western lifestyle. Indeed, acne is non-existent among primitive peoples, with a non-industrialized lifestyle.

Acne is a chronic inflammatory disease of the pilosebaceous unit (see diagram). The sebaceous gland produces sebum, which helps maintain the hydration of the epidermis, its suppleness and softness, as well as the balance of the skin's bacterial flora (skin microbiota). The functioning of the sebaceous glands is linked to hormonal activity: sebum production is particularly greater during adolescence or pregnancy, periods of high hormonal activity.

Acne is the direct consequence of three phenomena: - Seborrhea, consisting of excessive sebum production - Hyperproliferation of skin cells - Proliferation of the C. acnes bacteria leading to skin inflammation (relief on the skin and redness). The three phenomena mentioned above are themselves the consequence of different factors that interact with each other: - The cells of the sebaceous gland are very sensitive to hormones (insulin, IGF-1, androgen). During hormonal disorders, sebum production is altered (qualitatively and quantitatively), the channel at the entrance to the sebaceous gland becomes blocked and inflammatory phenomena arise. Excess androgens, estrogens, puberty and various hormonal fluctuations in women (pill, IUD, pregnancy) give rise to hormonal changes that can have an impact on acne.

- The role of the skin microbiota - the set of microorganisms present on the skin's surface. When the skin microbiota is balanced, good bacteria limit the growth of C. acnes (which is also always present) and limit the inflammatory reaction. But any infection, aggression, or bacterial resistance due to antibiotic use can cause overcolonization by C. acnes and an imbalance in the composition of the skin microbiota, causing skin inflammation. In treating acne, it is therefore not necessary to remove C. acnes but to restore the balance and the presence of other bacteria.

- Environmental factors play a major role in acne pathology because they promote an inflammatory process and weaken the microbiota (cutaneous and intestinal). Stress, lack of sleep, repeated medication use, tobacco, poor diet, and unsuitable cosmetics are factors that may contribute to the development of acne.

- Genetic predispositions : people whose parents had acne problems are more likely to suffer from it themselves. This hereditary process is now explained by the heredity of the skin microbiota. Understanding the origin of acne is important in order to establish an appropriate ritual in order to: rebalance the skin microbiota without attacking it regulate the secretion and composition of sebum reduce inflammation.

Understanding the origin of acne is important in order to establish a suitable ritual in order to: - rebalance the skin microbiota without attacking it
- regulate the secretion and composition of sebum
- reduce inflammation

The functions of the liver:

- stores fats and sugars in the form of glycogen, it produces lipoproteins to transport lipids, iron (ferritin)
- distributes nutrients from the intestine to the organs that need them
- synthesizes coagulation factors, growth hormone, vitamins (vitamin D)
- allows the digestion of fatty substances thanks to bile. Detoxification of the liver allows to sort and eliminate toxins and waste from the body thanks to enzymes such as cytochrome.

The toxins are:
- endogenous such as hormones; the liver is particularly important for the elimination of androgens which play a key role in acne,
but also - exogenous such as medicines, tobacco, alcohol, pesticides and other chemicals including endocrine disruptors

✔ Acne, hyperandrogenism, polycystic ovarian syndrome (PCOS)

✔ People on contraceptive pills, hyperestrogenism (breast tension, fibroids)

✔ People suffering from premenstrual syndrome

✔ Taking medication (overloads liver function), increased contact with pollution or other chemicals (tobacco, alcohol, pesticides)

✔ Migraines, chronic fatigue, sleep disorders, especially waking up after 4 a.m.

2 capsules in the morning with a glass of water, preferably on an empty stomach.

If this is unpleasant, you can take it with breakfast. 1 pillbox = 60 capsules = 1 month course of treatment